Respiration Problems. Promethazine/codeine may well induce slow or shallow respiration, particularly when you've got respiratory complications from Yet another problem or choose other medicines that can slow your respiration.
This Web page is employing a protection company to safeguard alone from on-line attacks. The action you just done induced the safety Remedy. There are many steps that may set off this block together with distributing a particular phrase or phrase, a SQL command or malformed details.
“Quite a few Group pharmacists currently not stock codeine linctus due to fears about habit and abuse.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric people below 6 many years of age, mainly because The mix might induce fatal respiratory melancholy in this age inhabitants.
The concomitant utilization of Promethazine HCl and Codeine Phosphate Oral Solution with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor could cause decrease codeine levels, bigger norcodeine ranges, and less metabolism through 2D6 with resultant lessen morphine amounts.
Promethazine and codeine ought to be applied for the duration of pregnancy provided that the likely reward justifies the likely risk on the fetus.
Prescription drug abuse is definitely the intentional non-therapeutic use of a prescription drug, even at the time, for its fulfilling psychological or physiological consequences.
Avoid using Promethazine HCl and Codeine Phosphate Oral Remedy in adolescents twelve to 18 decades of age who have other threat components that may increase their sensitivity to your respiratory depressant results of codeine. Chance things contain situations affiliated with hypoventilation, which include postoperative position, obstructive slumber apnea, weight problems, severe pulmonary illness, neuromuscular ailment, and concomitant utilization of other remedies that read more induce respiratory melancholy.
Take this medication just as directed to check here reduced the chance of addiction. Request your health practitioner or pharmacist For additional particulars.
If this SPL has inactivated NDCs outlined via website the FDA initiated compliance action, They are going to be specified therefore.
Overdose of codeine in Grownups has long been connected with deadly respiratory melancholy, and the usage of codeine more info in small children young than twelve yrs of age has long been related with fatal respiratory depression when used as encouraged [see Warnings and Safeguards (five.
Disposal of Unused Promethazine HCl and Codeine Phosphate Oral Alternative Advise patients to thoroughly get rid of unused Promethazine HCl and Codeine Phosphate Oral Option. Suggest clients to throw the drug within the home trash following these steps. one) Take out them from their authentic containers and mix them with an unwanted material, which include used espresso grounds or kitty litter (this tends to make the drug significantly less captivating to children and Animals, and unrecognizable to individuals that could intentionally go with the trash seeking drugs).
Codeine and its salts are well absorbed adhering to both oral and parenteral administration. Codeine is about two/three as successful orally as parenterally. Codeine is metabolized mostly in the liver by enzymes in the endoplasmic reticulum, where by it undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid.
Mainly because narcotic analgesics may perhaps raise biliary tract pressure with resultant increases in plasma amylase or lipase amounts, perseverance website of these enzyme amounts could possibly be unreliable for twenty-four several hours following a narcotic analgesic continues to be provided.